ProZyme, Inc., manufacturer of bioreagents for glycobiology, and BiOptic Inc. of Taiwan, manufacturer of instruments for DNA analysis by capillary gel electrophoresis (CGE), today announce an agreement to collaborate on the development and commercialization of an integrated system (Gly-Q™) for high-throughput, user-friendly glycoanalysis. The Gly-Q collaboration will extend ProZyme’s portfolio of glycobiology products, and will leverage BiOptic’s line of rugged and accurate CGE instruments.
Under the terms of the OEM/ODM licensing agreement, ProZyme will utilize BiOptic’s automated CGE platform with patented fluorescence detection and replaceable gel-cartridge design for rapid separation and detection of labeled glycans. At the front end of the Gly-Q system, enzymatically-released and fluorescently-labeled glycans will be prepared using ProZyme chemistry prior to glycan separation using the automated CGE instrument. Data analysis will be simplified by the use of customized software and ProZyme N-glycan reference standards. The combined Gly-Q system for N-glycan sample preparation, separation and analysis will be exclusively marketed by ProZyme worldwide.
Protein glycosylation is a post-translational modification that can influence the efficacy and safety of therapeutic proteins such as monoclonal antibodies. Traditional methods for glycan analysis involve slow and labor-intensive steps for sample preparation, glycan separation and data analysis. To this end, ProZyme and BiOptic plan to introduce the Gly-Q system to enable high-throughput and accessible glycoanalysis for use in applications such as biotherapeutic cell line development.
ProZyme will present preliminary data on use of the Gly-Q system for N-glycan analysis of biotherapeutics in a poster presentation at the California Separation Science Society (CASSS) CE Pharm meeting held in Brooklyn, NY, September 20-24, 2015. The commercialized ProZyme Gly-Q glycoanalysis workflow is expected to be available in early 2016.
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